Multiple Myeloma Articles and Abstracts – datanovia

Keywords

multiple myeloma, plasma cell cancer, biomarker discovery, prognosis

Introduction

Multiple myeloma is a hematological cancer characterized by the proliferation of malignant plasma cells in the bone marrow. It poses significant clinical challenges due to its complexity and resistance to therapy. Explore expert-level tutorials, tools, and abstracts addressing biomarker discovery, survival modeling, and therapeutic stratification in multiple myeloma.

List of Articles

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Proteasome Inhibitor Resistance Linked to Metabolic Deregulation in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Poster Presentation Multiple Myeloma Drug Resistance Whole Genome Sequencing Transcriptomic Analysis

Alboukadel Kassambara, 2022-06-23, in Scientific Abstracts

This study characterizes proteasome inhibitor-resistant myeloma cell lines and identifies resistance-driving mutations and metabolic reprogramming using whole genome and transcriptomic analyses.

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Metabolomic Score Predicts Drug Resistance in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Poster Presentation Multiple Myeloma Drug Resistance

Alboukadel Kassambara, 2022-06-23, in Scientific Abstracts

A gene expression-based metabolomic score derived from human myeloma cell lines reveals associations with drug resistance and poor prognosis in MM patients, supporting metabolic targeting as a…

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RNA-Seq–Based Risk Score with Prognostic and Theranostic Value in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma RNA Sequencing Risk Score

Alboukadel Kassambara, 2021-09-30, in Scientific Abstracts

This study defines a transcriptomic risk score derived from RNA-seq data that predicts prognosis and treatment response in multiple myeloma, enabling future applications in personalized medicine.

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Kinome Expression Profiling Reveals Prognostic Score and Therapeutic Targets in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Prognostic Biomarker Gene Expression

Alboukadel Kassambara, 2019-07-09, in Scientific Abstracts

This study identifies a kinome-based gene expression signature with prognostic value in multiple myeloma and proposes novel kinase inhibitors as promising therapeutic strategies, especially for…

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Mutational Landscape of Myeloma Cell Lines Identifies Drivers of Progression and Drug Resistance

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Exome Sequencing Mutational Profiling Drug Resistance

Alboukadel Kassambara, 2019-01-01, in Scientific Abstracts

This study presents a comprehensive exome-wide analysis of 30 human multiple myeloma cell lines (HMCLs), revealing key mutations, pathways, and drug response associations that help guide model…

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EZ Score Stratifies PRC2-Dependent Myeloma for Epigenetic Therapy

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Risk Score

Alboukadel Kassambara, 2018-10-03, in Scientific Abstracts

This study defines a gene expression–based EZ score for identifying high-risk multiple myeloma patients who may benefit from PRC2 inhibition and shows synergistic effects with IMiD therapy.

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DNMTi/HDACi Epigenetic Therapy Reprograms Myeloma Cells Toward Plasma Cell Maturity

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression Bioinformatics

Alboukadel Kassambara, 2018-03-02, in Scientific Abstracts

This study defines a gene expression–based Combo Score that predicts sensitivity to DNMTi/HDACi epigenetic therapy in multiple myeloma and shows that the combination reprograms malignant cells…

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RASSF4 Silencing Promotes RAS-Driven Progression in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression

Alboukadel Kassambara, 2018-03-01, in Scientific Abstracts

This study demonstrates that loss of RASSF4 expression, driven by promoter methylation, promotes multiple myeloma progression and resistance. RASSF4 reactivation re-sensitizes cells to MAPK and…

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Drug Metabolism Pathways Linked to Prognosis and Resistance in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Drug Resistance Gene Expression Survival Analysis

Alboukadel Kassambara, 2015-03-01, in Scientific Abstracts

This study shows how gene expression profiles of drug metabolism and clearance systems are linked to prognosis in multiple myeloma, identifying molecular signatures associated with chemoresistance.

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Epigenetic Therapy Alters Prognostic and Immune-Related Transcription in Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression

Alboukadel Kassambara, 2015-02-01, in Scientific Abstracts

This study characterizes the transcriptional response to in vivo treatment with HDAC and DNMT inhibitors in multiple myeloma, linking epigenetic reprogramming to prognosis and immune regulation.

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A DNA Repair Pathway Score Predicts Survival in Human Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma DNA Repair Prognostic Biomarker

Alboukadel Kassambara, 2014-05-15, in Scientific Abstracts

A DNA repair score (DRscore) derived from prognostic gene signatures accurately predicts survival in multiple myeloma and may guide personalized treatment strategies targeting synthetic lethality.

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Review of DNA Repair Pathways in Multiple Myeloma and Therapeutic Targeting

Scientific Contributions by Alboukadel Kassambara

Review Article Multiple Myeloma DNA Repair

Alboukadel Kassambara, 2013-08-09, in Scientific Abstracts

This review summarizes the roles of DNA repair mechanisms in multiple myeloma pathogenesis and treatment response, highlighting therapeutic opportunities targeting genomic instability.

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Inhibition of DEPDC1A Delays Growth and Induces Mature Markers in Myeloma Cells

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Prognostic Biomarker

Alboukadel Kassambara, 2013-04-30, in Scientific Abstracts

This study highlights DEPDC1A as a bad prognostic marker in multiple myeloma, showing that its inhibition delays growth and promotes differentiation of malignant plasma cells.

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Stem Cell–Associated Genes Predict Poor Prognosis in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Gene Expression Prognostic Biomarker

Alboukadel Kassambara, 2012-07-31, in Scientific Abstracts

This study identifies a prognostic stem cell–like gene expression signature unrelated to the cell cycle in multiple myeloma, leading to the development of a stem cell score (SCscore) predictive of…

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Scientific Abstracts

Selected Publications by Alboukadel Kassambara

Multiple Myeloma Risk Score Gene Expression Immunotherapy Bioinformatics

Alboukadel Kassambara, 2012-04-01, in Scientific Abstracts

Explore a curated selection of scientific abstracts authored by Alboukadel Kassambara, covering biomarker discovery, gene regulation, prognostic modeling, and bioinformatics applications in cancer…

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Genes with a Spike Expression Are Clustered on Specific Chromosome Regions with Prognostic Value in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Transcriptomic Analysis Gene Expression Prognostic Biomarker

Alboukadel Kassambara, 2012-04-01, in Scientific Abstracts

This study identifies genes with spike expression in multiple myeloma, reveals their clustering in chromosome bands, and introduces a spike band score with strong prognostic power for patient…

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