Review of DNA Repair Pathways in Multiple Myeloma and Therapeutic Targeting

Gourzones-Dmitriev C, Kassambara A, Sahota S, Rème T, Moreaux J, Bourquard P, Hose D, Pasero P, Constantinou A, Klein B. DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment. Cell Cycle. 2013. Download the PDF

Summary of the Study

Multiple myeloma (MM) is characterized by genetic instability and abnormal DNA repair activity, contributing to oncogenesis, treatment response, and resistance. This review synthesizes current understanding of:

• The role of DNA repair pathways in MM pathophysiology
• How primary translocations and disease progression involve genomic instability
• The impact of therapeutic agents like Melphalan and Bortezomib on DNA repair
• Opportunities for therapeutically targeting DNA repair machinery in MM

Improved insights into these processes may help identify synthetic lethal interactions and refine treatment strategies.

Important

In this study, Alboukadel Kassambara contributed to the writing of the review, synthesizing key literature on DNA repair pathways in multiple myeloma and their implications for targeted therapy.

Citation

Publication: In Cell Cycle
Date: August 9, 2013
Type: Review Article
PDF: Download the PDF

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Scientific Contributions

Note

Here are more scientific abstracts authored or co-authored by Alboukadel Kassambara. These contributions span computational biology, bioinformatics, biostatistics, machine learning, and multi-omics, with a focus on immuno-oncology and translational research.