Journal Article Articles and Abstracts – datanovia

Keywords

journal article, computational biology, biomedical data, precision medicine

Introduction

Peer-reviewed journal articles offer validated insights into scientific findings, methodologies, and applications. They form the foundation of reproducible research and clinical translation. Explore expert-level journal publications detailing computational biology, bioinformatics, and translational research.

List of Articles

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Immunoscore-IC Predicts Anti-PD1/PD-L1 Immunotherapy Response in Non-Small Cell Lung Cancer

Scientific Contributions by Alboukadel Kassambara

Journal Article Non-Small Cell Lung Cancer Immunotherapy Immunoscore-IC Digital Pathology

Alboukadel Kassambara, 2023-05-25, in Scientific Abstracts

Spatially resolved quantitative analysis of CD8 and PD-L1 markers using Immunoscore-IC enables prediction of response to immune checkpoint inhibitors in non-small cell lung cancer (NSCLC) patients.

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Immunoscore-IC Predicts ICI Benefit in Metastatic Colorectal Cancer

Scientific Contributions by Alboukadel Kassambara

Journal Article Colorectal Cancer Immunotherapy Immunoscore-IC Digital Pathology

Alboukadel Kassambara, 2023-04-01, in Scientific Abstracts

Digital quantification of tumor lymphocyte infiltration using Immunoscore and Immunoscore-IC predicts benefit from anti-PD-L1 therapy in pMMR metastatic colorectal cancer (mCRC), based on the…

A

AtezoTRIBE Trial: Atezolizumab Plus FOLFOXIRI Improves PFS in Metastatic Colorectal Cancer

Scientific Contributions by Alboukadel Kassambara

Journal Article Colorectal Cancer Immunotherapy Immunoscore-IC Survival Modeling

Alboukadel Kassambara, 2022-05-27, in Scientific Abstracts

The AtezoTRIBE phase 2 trial demonstrates that adding atezolizumab to FOLFOXIRI-bevacizumab improves progression-free survival in metastatic colorectal cancer patients. Biomarker-based survival…

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Immunoscore Outperforms Visual Scoring in Colon Cancer Immune Assessment

Scientific Contributions by Alboukadel Kassambara

Journal Article Colorectal Cancer Digital Pathology Data Visualization

Alboukadel Kassambara, 2022-02-24, in Scientific Abstracts

This study compares Immunoscore—a standardized digital pathology tool—with pathologist visual scoring in early-stage colon cancer, demonstrating the superior accuracy and reproducibility of…

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RNA-Seq–Based Risk Score with Prognostic and Theranostic Value in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma RNA Sequencing Risk Score

Alboukadel Kassambara, 2021-09-30, in Scientific Abstracts

This study defines a transcriptomic risk score derived from RNA-seq data that predicts prognosis and treatment response in multiple myeloma, enabling future applications in personalized medicine.

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RNA-Seq Dissection of Plasma Cell Differentiation Reveals Novel Transcriptional Regulators

Scientific Contributions by Alboukadel Kassambara

Journal Article Plasma Cell Differentiation RNA Sequencing Gene Expression

Alboukadel Kassambara, 2021-04-06, in Scientific Abstracts

This study maps the gene expression program across temporal stages of human plasma cell differentiation using RNA-seq, identifying new transcriptional regulators involved in cell maturation and…

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Gene Expression–Based Risk Score for Prognosis in Diffuse Large B-Cell Lymphoma

Scientific Contributions by Alboukadel Kassambara

Journal Article DLBCL Gene Expression Risk Score Prognostic Biomarker

Alboukadel Kassambara, 2019-07-22, in Scientific Abstracts

This study builds a prognostic gene expression–based risk score from B-cell marker genes in DLBCL and demonstrates its clinical relevance in stratifying patient survival outcomes.

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Kinome Expression Profiling Reveals Prognostic Score and Therapeutic Targets in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Prognostic Biomarker Gene Expression

Alboukadel Kassambara, 2019-07-09, in Scientific Abstracts

This study identifies a kinome-based gene expression signature with prognostic value in multiple myeloma and proposes novel kinase inhibitors as promising therapeutic strategies, especially for…

M

Mutational Landscape of Myeloma Cell Lines Identifies Drivers of Progression and Drug Resistance

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Exome Sequencing Mutational Profiling Drug Resistance

Alboukadel Kassambara, 2019-01-01, in Scientific Abstracts

This study presents a comprehensive exome-wide analysis of 30 human multiple myeloma cell lines (HMCLs), revealing key mutations, pathways, and drug response associations that help guide model…

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EZ Score Stratifies PRC2-Dependent Myeloma for Epigenetic Therapy

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Risk Score

Alboukadel Kassambara, 2018-10-03, in Scientific Abstracts

This study defines a gene expression–based EZ score for identifying high-risk multiple myeloma patients who may benefit from PRC2 inhibition and shows synergistic effects with IMiD therapy.

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EpiScore Predicts Prognosis and Therapeutic Potential in DLBCL

Scientific Contributions by Alboukadel Kassambara

Journal Article DLBCL Epigenetics Risk Score Prognostic Biomarker

Alboukadel Kassambara, 2018-04-10, in Scientific Abstracts

This study defines EpiScore, a gene expression–based risk score from epigenetic regulators, to predict survival in diffuse large B cell lymphoma and identify patients likely to benefit from…

D

DNMTi/HDACi Epigenetic Therapy Reprograms Myeloma Cells Toward Plasma Cell Maturity

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression Bioinformatics

Alboukadel Kassambara, 2018-03-02, in Scientific Abstracts

This study defines a gene expression–based Combo Score that predicts sensitivity to DNMTi/HDACi epigenetic therapy in multiple myeloma and shows that the combination reprograms malignant cells…

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RASSF4 Silencing Promotes RAS-Driven Progression in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression

Alboukadel Kassambara, 2018-03-01, in Scientific Abstracts

This study demonstrates that loss of RASSF4 expression, driven by promoter methylation, promotes multiple myeloma progression and resistance. RASSF4 reactivation re-sensitizes cells to MAPK and…

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Global miRNA Expression Analysis Identifies Novel Key Regulators of Plasma Cell Differentiation and Malignant Plasma Cell

Scientific Contributions by Alboukadel Kassambara

Journal Article Plasma Cell Differentiation Bioinformatics

Alboukadel Kassambara, 2017-06-02, in Scientific Abstracts

Comprehensive integrated analysis of miRNA and mRNA dynamics during plasma cell differentiation identifies novel key regulators with implications in multiple myeloma.

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RECQ Helicases Are Deregulated in Hematologic Cancers and Linked to Prognosis

Scientific Contributions by Alboukadel Kassambara

Journal Article Gene Expression Prognostic Biomarker

Alboukadel Kassambara, 2016-02-13, in Scientific Abstracts

This study shows that expression of RECQ helicases is altered in hematological malignancies and is associated with prognosis, supporting their role as potential therapeutic targets.

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Drug Metabolism Pathways Linked to Prognosis and Resistance in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Drug Resistance Gene Expression Survival Analysis

Alboukadel Kassambara, 2015-03-01, in Scientific Abstracts

This study shows how gene expression profiles of drug metabolism and clearance systems are linked to prognosis in multiple myeloma, identifying molecular signatures associated with chemoresistance.

E

Epigenetic Therapy Alters Prognostic and Immune-Related Transcription in Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Epigenetics Gene Expression

Alboukadel Kassambara, 2015-02-01, in Scientific Abstracts

This study characterizes the transcriptional response to in vivo treatment with HDAC and DNMT inhibitors in multiple myeloma, linking epigenetic reprogramming to prognosis and immune regulation.

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GenomicScape: An Easy-to-Use Web Tool for Gene Expression Data Analysis. Application to Investigate the Molecular Events in the Differentiation of B Cells into Plasma Cells

Scientific Contributions by Alboukadel Kassambara

Journal Article Bioinformatics Plasma Cell Differentiation Transcriptomic Analysis Web Applications

Alboukadel Kassambara, 2015-01-29, in Scientific Abstracts

GenomicScape is a free and interactive platform for mining transcriptome data across B cell differentiation stages. This study demonstrates its application for visualizing and clustering gene…

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A DNA Repair Pathway Score Predicts Survival in Human Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma DNA Repair Prognostic Biomarker

Alboukadel Kassambara, 2014-05-15, in Scientific Abstracts

A DNA repair score (DRscore) derived from prognostic gene signatures accurately predicts survival in multiple myeloma and may guide personalized treatment strategies targeting synthetic lethality.

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Inhibition of DEPDC1A Delays Growth and Induces Mature Markers in Myeloma Cells

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Prognostic Biomarker

Alboukadel Kassambara, 2013-04-30, in Scientific Abstracts

This study highlights DEPDC1A as a bad prognostic marker in multiple myeloma, showing that its inhibition delays growth and promotes differentiation of malignant plasma cells.

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Stem Cell–Associated Genes Predict Poor Prognosis in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Gene Expression Prognostic Biomarker

Alboukadel Kassambara, 2012-07-31, in Scientific Abstracts

This study identifies a prognostic stem cell–like gene expression signature unrelated to the cell cycle in multiple myeloma, leading to the development of a stem cell score (SCscore) predictive of…

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Genes with a Spike Expression Are Clustered on Specific Chromosome Regions with Prognostic Value in Multiple Myeloma

Scientific Contributions by Alboukadel Kassambara

Journal Article Multiple Myeloma Transcriptomic Analysis Gene Expression Prognostic Biomarker

Alboukadel Kassambara, 2012-04-01, in Scientific Abstracts

This study identifies genes with spike expression in multiple myeloma, reveals their clustering in chromosome bands, and introduces a spike band score with strong prognostic power for patient…

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