Viziteu E, Kassambara A, Pasero P, Klein B, Moreaux J. RECQ helicases are deregulated in hematological malignancies in association with a prognostic value. Biomarker Research. 2016. Download the PDF
Summary of the Study
RECQ helicases maintain genome integrity by regulating DNA repair in response to genotoxic stress. Their deregulation may contribute to the genomic instability observed in hematological malignancies.
In this study:
Expression profiles of RECQ family genes were examined across:
- Acute myeloid leukemia
- Chronic lymphocytic leukemia
- Lymphoma
- Multiple myeloma
Public transcriptomic datasets were used to compare tumor vs. normal expression
At least one RECQ gene was found significantly deregulated in each malignancy
Certain RECQ members showed strong prognostic value, identifying high-risk patients
In this study, Alboukadel Kassambara contributed to the bioinformatic analysis of gene expression data, focusing on the expression and prognostic relevance of RECQ helicase family genes across hematologic cancers.
Citation
Publication: In Biomarker Research
Date: February 13, 2016
Type: Journal Article
PDF: Download the PDF
Scientific Contributions
Here are more scientific abstracts authored or co-authored by Alboukadel Kassambara. These contributions span computational biology, bioinformatics, biostatistics, machine learning, and multi-omics, with a focus on immuno-oncology and translational research.
